Ketone Reduction Using Sodium Borohydride

Experiment 5B Ketone Reduction mark Using sodium borohydride as a decrease agent, the ketone 4-tert-butylcyclohexane is reduced to its corresponding alcohol. It is purified finished extraction techniques to give the cis and trans diasteromer mathematical products. Procedure The surgical process was followed as outlined in mayos book for Experiment 5B with the by-line modifications 1. Reagents and Equipment The chemical reaction will be on a scale of 2X what is described in the text. 2. Reagents and Equipment The build of the reaction will be followed by tender loving care as tell in the chemical reaction Conditions share.Glass backed tender loving care plates will be created with the following terce spots Ketone Standard/Co-Spot/Crude Reaction Mixture. Prepare the tender loving care plate bit the reaction is being set up. To the initial solution of 4-tert-butylcyclohexane in methanol, before working the reducing solution, insert a TLC capillary. part this sample as y our ketone standard. Do not stop the reaction before checking the progress by TLC. If the reaction is not complete, add another portion of the reducing solution. 3. isolation of Product All other amounts stipulate in this section should be followed without doubling. . isolation of Product Substitute 1. 0 mL of cold 3. 0 M HCl for 1. 0 mL of cold 0. 1 M HCl. 5. Purification and Characterization Will not obtain an NMR spectrum. Reaction arrangement of rules Data and Results CompoundMW (g/mol)AmountMmolMp (degrees C)Bp (degrees C) 4-tert-butylcylcohexane154. 25103 mg0. 6747 50 Methanol32. 04100 L65 Sodium Borohydride reducing solution37. 83200 L *NOTE As I was condensing my product in the sense bath it popped and there was no more than final product in my vial. hence I was not able to do a final analysis and I am using Mike Marianis data in my report.Observations 1. Crude product was solid and white in pretension. 2. TLC spots were dark purple for both the ketone standard a nd co-spot. The spot for the crude reaction mixture was barely visible. 3. Melting token of product started at 62. 5 degrees Celsius. Calculations 1. TLC was done in an elution solvent system of ethyl acetate hexane (14). QQ did not energise us record Rf values. The color of the spots was as indicated in the observations section above. 2. show of Crude Product = ampul and product Vial 4. 233 g 4. 141 = 0. 092 g = 92 mg 3. Percent Yield of Crude Product